Nikhil Jayaram, MD

Biography

Research Interests

His research interests focus on pathophysiology of abdominal pain in pancreatitis, pancreatic calculi management, exocrine and endocrine pancreatic dysfunction, organ failure in severe acute pancreatitis, management of pancreatic fluid collections and the early detection and surveillance of high-grade neoplasia in mucinous pancreatic cystic lesions. He is particularly interested in refining risk stratification tools, exploring disease mechanisms, and leveraging pancreatobiliary endoscopy to develop innovative, minimally invasive/ non-invasive approaches for the management of pancreatic disorders

Publications

1. Bush N, Khashab M, Akshintala VS. Current and Emerging Applications of Artificial
Intelligence (AI) in the Management of Pancreatobiliary (PB) disorders. Curr Gastroenterol
Rep. 2024 Nov;26(11):304–9.
2. Bush N, Yazici C, Han SY, Lee PJ, Abu-El-Haija M, Akshintala VS. Assessment of Medical
Pancreatology Fellowship Training in the United States: A Collaborative Alliance for Pancreatic
Education and Research (CAPER) initiative. Pancreas. 2024 Aug
12;10.1097/MPA.0000000000002406.
3. Bush N, Chandragiri P, Gaurav NA, Sonaiya S, Lahooti I, Singh A, et al. Development of a
novel CT-based index for predicting the number of extracorporeal shockwave lithotripsy
(ESWL) sessions required for successful fragmentation of obstructing pancreatic duct
stones. Pancreatol Off J Int Assoc Pancreatol IAP Al. 2024 Mar 28;S1424-3903(24)00079-
6.
4. Singh A, Swei E, Tolosa C, Alverson M, Brenner TA, Kaur A, Bush N et al. Development
of an Automated Endoscopic Retrograde Cholangiopancreatography Quality Report Card
Using an Integrated Analytics Suite. Tech Innov Gastrointest Endosc [Internet]. 2024 Mar
27 [cited 2024 Apr 15]
5. Metri A, Bush N, Singh VK. Predicting the severity of acute pancreatitis: Current
approaches and future directions. Surg Open Sci. 2024 Jun 1;19:109–17.
6. Bush N, Han S, Akshintala VS. Extra-Corporeal Shock Wave Lithotripsy for Pancreatic Duct Calculi:
A Perspective From a Practice in the United States. Pancreas. 2024 Feb 1;53(2):e223–4.
7. Rana SS, Bush N, Sharma R, Gupta R. Impact of Direct Endoscopic Necrosectomy on
Recurrence of Symptoms or Fluid Collections Following Successful Endoscopic
Transmural Drainage of Walled-off Necrosis in Disconnected Pancreatic Duct. J Dig
Endosc. 2023 Dec;14(04):185–90.
8. Nagy R, Ocskay K, Sipos Z, N Bush et al. Discharge protocol in acute pancreatitis: an
international survey and cohort analysis. Sci Rep. 2023 Dec 13;13(1):22109.
9. Bush N, Akshintala VS. Interpretation of serum pancreatic enzymes in pancreatic and
nonpancreatic conditions. Curr Opin Gastroenterol. 2023 Sep 1; 39(5): 403–10.
10. Bush N, Gupta R, Rana SS. Endoscopic Removal of Pancreatic Duct Stent Broken into
Multiple Intra-ductal Fragments. Dig Dis Sci. 2023 Aug; 68(8): 3201–2.
11. Goenka MK, Akshintala VS, Kamal A, Bhullar FA, Bush N, Kumar V, et al. Frequent
guidewire passage into the pancreatic duct is an independent risk factor for
postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) among
high-risk individuals: A post-hoc analysis of a randomized controlled trial data. J Dig Dis.
2023 Jul 28;
12. Bush N, Singh VK. Pancreatic exocrine insufficiency guidelines: more questions than
answers! Hepatobiliary Surg Nutr. 2023 Jun 1; 12(3): 428–30.
13. Bush N, Rana SS. Endoscopic Ultrasound Biopsy Needle. J Dig Endosc. 2022 Dec; 13(04):
240–2.
14. Akshintala VS, Husain SZ, Brenner TA, Singh A, Singh VK, Khashab MA, Bush N et al.
Rectal INdomethacin, oral TacROlimus, or their combination for the prevention of postERCP pancreatitis (INTRO Trial): Protocol for a randomized, controlled, double-blinded
trial. Pancreatol Off J Int Assoc Pancreatol IAP Al. 2022 Nov; 22(7): 887–93.
15. Sharma RK, Bush N, Rana SS, Srinivasan R, Nada R, Gupta R, et al. Lower cyst fluid
carcinoembryonic antigen cutoff is helpful in the differential diagnosis of mucinous
carcinoembryonic antigen cutoff is helpful in the differential diagnosis of mucinous
versus non-mucinous pancreatic cysts. Indian J Gastroenterol Off J Indian Soc
Gastroenterol. 2022 Aug; 41(4): 397–404.
16. Bush N, Rana SS. Ascites in Acute Pancreatitis: Clinical Implications and Management. Dig
Dis Sci. 2022 Jun; 67(6): 1987–93.
17. Rao C, Bush N, Rana SS, Sharma RK, Rana S, Jeyashree K, et al. Plasma Osteopontin
Levels as an Early Predictor of Mortality in Acute Pancreatitis: A Preliminary Study.
Pancreas. 2022 May 1; 51(5): e77–9.
18. Singh S, Bush N, Taneja S.

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