Gene Siegal, MD, PhD

Biography

Title

Interim Chair, Department of Genetics, Executive Vice Chair, Department of Pathology, Mowry Endowed Professor of Pathology, Former Division Director, Anatomic Pathology

Faculty Appointment

Professor

Research Interests

Dr. Siegal is an extramurally funded experimental and diagnostic pathologist whose research interest for more than 4 decades has been focused in Cancer Biology. Specifically, he has been interested in studying tumor-matrix interactions during angiogenesis, tumor invasion and metastasis in breast cancer. Previous efforts by his group have been directed towards developing new reliable in vitro model systems for studying the effect of nutritional and other factors on prostate and breast cancer progression in humans. He has participated in multiple gene therapy studies utilizing a variety of distinct strategies including mutation compensation, genetic immunopotentiation, and molecular chemotherapy to treat solid human neoplasms, principally ovarian carcinoma. He was most recently funded to develop a conditionally replicating canine adenovirus model that could be used to study host-vector interactions for more effective antitumor oncolytic effect. Dr. Siegal also directs the Pathology Core Research Laboratory/Department of Pathology. Dr. Siegal's clinical research interests have focused on studies of bone tumors and related conditions. He is the Editor-in-Chief of Laboratory Investigation and serves on the editorial board of multiple additional journals.

Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gene+P+Siegal

Awards & Recognition

A.S.I.P. Robbins Distinguished Educator Award 2015
Albert Nelson Marquis Lifetime Achievement Award 2017
C.A.P. Lifetime Achievement Award 2017

Memberships

American Society for Clinical Pathology (ASCP), American Society for Investigative Pathology (ASIP), College of American Pathologists (CAP), American Medical Association (AMA), Association of Clinical Scientists (ACS), American Association for Cancer Research (AACR), Alpha Omega Alpha (AOA), Sigma Xi