Christopher Willey, MD, PhD
Radiation Oncology
Highlights
Age Groups Seen
- Adults
- Geriatrics
Languages
- English
About Christopher Willey
Title
Associate Professor, Director of UAB Kinome Core
Faculty Appointment
Professor
Research Interests
1. UAB Kinome Core: (Director: Christopher D. Willey) Investigating kinase driven signal transduction cascades in a spectrum of biological systems (in vitro to in vivo), particularly related to cancer, but also other kinase driven diseases. This core utilizes a high-content peptide array platform (PamStation®12) that measures global kinase activity in cell and tissue lysates providing broad basic and translational potential. Several collaborations are ongoing across UAB campus and with other Universities and Institutes. An emphasis of the core is to develop personalized medicine approaches through evaluation of kinomic profiles in tumor specimens coupled with ex vivo profiling of small molecule inhibitors (kinase inhibitors) to guide therapy selection. Specific cancers tested include: Glioblastoma, melanoma, meningioma, lung cancer, breast cancer, head and neck cancer, leukemia, renal cell cancer, penile cancer, bladder cancer, and pancreas cancer. Several non-cancer emphases include: IgA Nephropathy, Immunology, and Schizophrenia.
2. Bioinformatics for kinomics and personalized medicine: This research collaboration involves the development of Web-based bioinformatics solutions to connect high content data, including kinomics data, with public and private “omic” databases. We are developing web-based resources (open source) for investigators to analyze kinomics data. In addition, we are developing Javascript biostatistical resources in an “app store” environment. This will allow for improved access to peer-reviewed statistical tools to work in a web-based environment. This collaboration involves Dr. Jake Chen.
3. Preclinical models and Systems Biology approaches in Glioblastoma multiforme (GBM): In collaboration with G. Yancey Gillespie, Raj Singh, and Jake Chen, we are evaluating ways to use high content data to make therapeutic decisions in GBM beginning in patient derived xenolines with the ultimate goal of doing so in patients. We have tried to miniaturize this through the use of 3D MicroTumor culture system with drug combination testing. We have created a “Proband” model of the disease and are moving towards a clinical trial paradigm.
4. MARCKS and Cancer biology as well as radiation response modulation: Investigating the protein Myristoylated Alanine Rich C-Kinase Substrate (MARCKS) in the context of tumor biology and tumor immunology. This project is focused on MARCKS impact on GBM biology. The intent is to identify the pertinent functional domain of MARCKS and to develop MARCKS targeted therapies, including small peptide therapeutics. A new direction is in the setting of tumor microenvironment and cancer stem cells.
5. Clinical/translational Research: I have particular focus in brain, lung, and head and neck cancer trials. I am a co-investigator on several clinical trials in these disease sites. In addition, I am developing collaborations with industry for translational research with patient-derived xenograft development and multi-omic testing of patient tumors. With the advent of high dose rate proton therapy, I am a member of the FLASH FORWARD research consortium evaluating the potential clinical development of FLASH therapy.
Memberships
Alabama Society of Radiation Oncology
Alpha Omega Alpha Medical Fraternity
American Association for Cancer Research
American College of Radiation Oncology
American Society of Clinical Oncology
American Society for Therapeutic Radiology and Oncology
Medical Association of the State of Alabama
Roentgen Society of Vanderbilt
Radiosurgery Society
View Academic Profile
Locations
- Radiation Oncology at The Kirklin Clinic at Acton Road
- 2145 Bonner Way, Floor 1, Birmingham, AL 35243
- Get Directions
- phone: 205-934-5670
- Radiation Oncology at Hazelrig-Salter Radiation Oncology Center
- 1700 6th Avenue South, Birmingham, AL 35233
- Get Directions
- phone: 205-934-5670
Expertise
Education
- Residency: Vanderbilt University Medical Center, 2008
- Internship: Spartanburg Regional Medical Center, 2004
- Graduate School: Medical University of South Carolina, 2003
- Medical School: Medical University of South Carolina, 2003
Board Certifications
- Radiation Oncology: American Board of Radiology, 2009
Ratings & Reviews
5 of 5 stars
43 ratings, 20 reviewsThe Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
- 5 out of 5 starsReviewed on 3/18/2026
Kindness shown
- 5 out of 5 starsReviewed on 2/25/2026
I was treated with respect Every one was very nice. No one was rude and I love seeing my doctor.
- 5 out of 5 starsReviewed on 2/25/2026
Everyone was fantastic. Friendly and welcoming. Even the valet went above and beyond.
- 5 out of 5 starsReviewed on 2/25/2026
Very pleased
- 5 out of 5 starsReviewed on 2/11/2026
Dr Willey explained everything
- 5 out of 5 starsReviewed on 1/21/2026
Dr Willey saying that everything looked good!
- 5 out of 5 starsReviewed on 1/21/2026
Dr willey is really and every one is so nice and kind.
- 5 out of 5 starsReviewed on 12/12/2025
It was great 👍
- 5 out of 5 starsReviewed on 11/19/2025
The staff is professional and friendly. The doctors are very knowledgeable and supportive. To me the very best
- 5 out of 5 starsReviewed on 10/3/2025
Everybody is very cheerful.
- 5 out of 5 starsReviewed on 9/24/2025
Busy day; took awhile; but always well treated and worth the wait.
- 5 out of 5 starsReviewed on 9/22/2025
Dr. Willey and staff are amazing and dedicated to their profession. They really care and it shows every time I come in for my yearly check up.
- 5 out of 5 starsReviewed on 9/17/2025
Nice helpful staff. No problems.
- 5 out of 5 starsReviewed on 9/12/2025
This was my first appointment with Dr. Willey. I was more than pleased with his thorough review of my case from previous PET scans to the surgery and pathology reports that I brought from my surgeon. He explained everything on my case in a very understandable and patient manner. I look forward to him being my radiation oncologist.
- 5 out of 5 starsReviewed on 8/15/2025
Great location for out of town visits.
- 5 out of 5 starsReviewed on 8/8/2025
They have treated me many times in radiology and never a complaint.
- 5 out of 5 starsReviewed on 8/6/2025
I have over the years received outstanding medical service,treatment and advice from Dr Willey and his staff have always been courteous,professional and respectful.
- 5 out of 5 starsReviewed on 6/18/2025
Smooth operation to get scheduled and serviced by polite and knowledgeable business and medical staff.
- 5 out of 5 starsReviewed on 5/25/2025
Was very nice
- 5 out of 5 starsReviewed on 4/30/2025
Dr. Willey is the best. He is so personable. Excellent bedside manner. Great professor. The staff is second to none.